May/June 2026 Paper 12

2026 · 40 questions · 40 parts · 40 marks

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25Dna Structure ReplicationMedium1 mark
In cancer cells, the production of DNA ligase is upregulated, meaning it is produced in larger quantities than in a normal cell. Several potential anticancer drugs are being designed as inhibitors to this enzyme as a mechanism for preventing DNA replication in cancerous cells. How does the inhibition of DNA ligase prevent successful DNA replication in cancerous cells?